(378) Optogenetic inhibition sensory neurons mediating bladder nociception
نویسندگان
چکیده
منابع مشابه
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Inflammatory pain is thought to be mediated in part through the action of inflammatory mediators on membrane receptors of peripheral nerve terminals, however, the downstream signaling events which lead to pain are poorly understood. In this study we investigated the nociceptive pathways induced by activation of protease-activated receptor 2 (PAR-2) in damage-sensing (nociceptive) neurons from r...
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متن کاملOptogenetic inhibition of neurons by internal light production
Optogenetics is an extremely powerful tool for selective neuronal activation/inhibition and dissection of neural circuits. However, a limitation of in vivo optogenetics is that an animal must be tethered to an optical fiber for delivery of light. Here, we describe a new method for in vivo, optogenetic inhibition of neural activity using an internal, animal-generated light source based on firefl...
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Glutamatergic pathways mediate transmission of pain. Strategies to reduce glutamatergic neurotransmission may have beneficial effects to mitigate nociception. Recent work revealed that overexpression of the astrocytic glutamate transporter (GLT-1) by transgenic or pharmacologic approaches produced a diminished visceral nociceptive response to colonic distension. The purpose of this study was to...
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CYCLOPHOSPHAMIDE-INDUCED CYSTITIS REDUCES ASIC CHANNEL, BUT 1 ENHANCES TRPV1 RECEPTOR FUNCTION IN RAT BLADDER SENSORY NEURONS 2 3 Khoa Dang Klaus Bielefeldt and G.F. Gebhart 4 Departments of Pharmacology and Medicine, Carver College of Medicine, The 5 University of Iowa, Iowa City, IA 52242 6 7 8 Running title: Cystitis reduces ASIC but increases TRPV1 function 9 10 11 Author for correspondence...
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ژورنال
عنوان ژورنال: The Journal of Pain
سال: 2016
ISSN: 1526-5900
DOI: 10.1016/j.jpain.2016.01.285